The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

@article{Luhmann2009TheDP,
  title={The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.},
  author={Ulrich F. O. Luhmann and Scott J. Robbie and Peter M. G. Munro and Susie E. Barker and Yana{\'i} Dur{\'a}n and Vy Luong and Frederick W. Fitzke and James W B Bainbridge and Robin R Ali and Robert E Maclaren},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 12},
  pages={5934-43}
}
PURPOSE Drusen, which are defined clinically as yellowish white spots in the outer retina, are cardinal features of age-related macular degeneration (AMD). Ccl2-knockout (Ccl2(-/-)) mice have been reported to develop drusen and phenotypic features similar to AMD, including an increased susceptibility to choroidal neovascularization (CNV). This study was conducted to investigate the nature of the drusenlike lesions in vivo and further evaluate the Ccl2(-/-) mouse as a model of AMD. METHODS The… CONTINUE READING
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