The druggable genome
@article{Hopkins2002TheDG, title={The druggable genome}, author={A. Hopkins and C. Groom}, journal={Nature Reviews Drug Discovery}, year={2002}, volume={1}, pages={727-730} }
An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry. Now that we know the size of the human genome, it is interesting to consider just how many molecular targets this opportunity represents. We start from the position that we understand the properties that are required for a good drug, and therefore must be able to understand what makes a… CONTINUE READING
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References
SHOWING 1-10 OF 17 REFERENCES
In vivo drug target discovery: identifying the best targets from the genome.
- Medicine, Biology
- Current opinion in biotechnology
- 2001
- 41
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
- Biology, Medicine
- Nature Biotechnology
- 2001
- 954
- PDF
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.
- Medicine
- Advanced drug delivery reviews
- 2001
- 7,318
- PDF
Effect of slow growth on metabolism of Escherichia coli, as revealed by global metabolite pool ("metabolome") analysis.
- Biology, Medicine
- Journal of bacteriology
- 1998
- 333
- PDF