The drug resistance-related protein LRP is the human major vault protein

@article{Scheffer1995TheDR,
  title={The drug resistance-related protein LRP is the human major vault protein},
  author={George L. Scheffer and Peter L. J. Wijngaard and Marcel J. Flens and Miguel Angel Izquierdo and Marilyn L. Slovak and Herbert Michael Pinedo and Chris J.L.M. Meijer and Hans Clevers and Rik J. Scheper},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={578-582}
}
Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein. Vaults are multi-subunit structures that may be… Expand
Relationship of LRP-human major vault protein toin vitro and clinical resistance to anticancer drugs
TLDR
LRP expression at diagnosis has been shown to be a strong and independent prognostic factor for response to chemotherapy and outcome in acute myeloid leukemia and ovarian carcinoma patients, and LRP's predictive value extended to MDR unrelated drugs, such as platinum compounds. Expand
Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer
TLDR
Clinical data indicate that LRP/MVP expression can be of high clinical value to predict the response to chemotherapy of several tumor types and the composition of vaults is almost unraveled. Expand
Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter.
TLDR
DNA sequences upstream to the transcription initiation site of the MVP gene in the human non-small cell lung cancer cell line SW-1573 are characterized and show strong promoter activity in chloramphenicol acetyltransferase (CAT) reporter assays. Expand
Direct activation of the human major vault protein gene by DNA-damaging agents.
TLDR
Investigation of whether anticancer drugs could directly induce MVP protein or gene expression in the SW-620 human colorectal cancer cell line suggests that DNA damage enhances MVP promoter activity. Expand
Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells.
TLDR
LRP is involved in resistance to doxorubicin, vincristine, etoposide, paclitaxel, and gramicidin D and has an important role in the transport of doxorbicin from the nucleus to the cytoplasm. Expand
Major vault protein LRP-related multidrug resistance.
TLDR
Frequently, upon exposure to natural product drugs, mammalian cells acquire resistance to many structurally and functionally unrelated compounds, including anthracyclines, epipodophyllotoxins, vinca alkaloids and taxanes. Expand
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.
TLDR
Observations indicate that vault formation is limited not only by the expression of the MVP but also by theexpression or assembly of at least one of the other vault proteins. Expand
Alterations in the expression of daunorubicin phase-I metabolising enzymes in different carcinoma cell lines.
TLDR
The overexpression of two plasma membrane transporters, termed glycoprotein P-170 (MDR1) and multidrug resistance related protein (MRP), and the metabolism of cytostatics could contribute to a lower toxicity and failure of chemotherapy. Expand
Major vault protein/lung resistance-related protein (MVP/LRP) expression in nervous system tumors
TLDR
Neither the presence nor the degree of immunoreactivity to MVP/LRP showed any correlation with either tumor grade or the presence of brain invasion in primary central nervous system tumors. Expand
Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines
TLDR
The data suggest that LRP expression may be an important determinant of the MDR phenotype in cell lines intrinsically resistant to cancer chemotherapeutic agents. Expand
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