The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing.

@article{Ederth2002TheDD,
  title={The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing.},
  author={Josefine Ederth and Irina Artsimovitch and Leif A. Isaksson and Robert Landick},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 40},
  pages={37456-63}
}
Regulation of RNA polymerase during initiation, elongation, and termination of transcription is mediated in part by interactions with intrinsic regulatory signals encoded in the RNA and DNA that contact the enzyme. These interactions include contacts to an 8-9-bp RNA:DNA hybrid within the active-site cleft of the enzyme, contacts to the melted nontemplate DNA strand in the vicinity of the hybrid, contacts to exiting RNA upstream of the hybrid, and contacts to approximately 20 bp of duplex DNA… CONTINUE READING

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