The down-regulation of galectin-1 expression is a specific biomarker of arsenic toxicity.

@article{Chang2011TheDO,
  title={The down-regulation of galectin-1 expression is a specific biomarker of arsenic toxicity.},
  author={Yu-ying Chang and M. -C. Chiang and Tai-Chih Kuo and Li-Ling Chi and Yung-hsi Kao and Runjun Huang},
  journal={Toxicology letters},
  year={2011},
  volume={205 1},
  pages={
          38-46
        }
}
Galectin-1 (GAL1) is known as a β-galactoside-binding protein that also can bind with arsenic to regulate cell functions. Using RNA interference technique, we investigated the possible mechanism involved in GAL1 modulation of arsenite-inhibited cell survival in 3T3 fibroblast and KB oral cancer cells. GAL1 gene knockdown significantly attenuated sodium arsenite (NaAsO(2)) and arsenic trioxide (As(2)O(3)) inhibition of cell survival. However, GAL1 gene knockdown did not alter the inhibition of… CONTINUE READING
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