The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.

@article{RiveraMarrero2004TheDO,
  title={The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.},
  author={Carlos A Rivera-Marrero and Julie L Stewart and William M. Shafer and Jesse Roman},
  journal={Infection and immunity},
  year={2004},
  volume={72 10},
  pages={5712-21}
}
Cathepsin G (CatG) is a serine protease found in the azurophilic granules of monocytes that is known to have antimicrobial properties, but its role in Mycobacterium tuberculosis infection is unknown. We found that M. tuberculosis infection of human THP-1 monocytic cells induced the down-regulation of CatG mRNA expression, as demonstrated by gene array… CONTINUE READING