The double-strand-break repair model for recombination

@article{Szostak1983TheDR,
  title={The double-strand-break repair model for recombination},
  author={Jack W. Szostak and Terry L. Orr-Weaver and Rodney Rothstein and Franklin William Stahl},
  journal={Cell},
  year={1983},
  volume={33},
  pages={25-35}
}

DNA double-strand break repair: genetic determinants of flanking crossing-over.

TLDR
It is demonstrated that a double-strand gap can be repaired through gene conversion copying a homologous duplex, as predicted by the double-Strand break repair models, in the RecE pathway of Escherichia coli.

DNA End-Processing and Heteroduplex DNA Formation During Recombinational Repair of DNA Double-Strand Breaks

TLDR
This article will provide an account of what is currently known about homologous recombination and its DNA repair role and suggest that the former appears to be the more critical mechanism in the G1 phase and the latter taking on a prominent role in late S and G2 when a sister chromatid becomes available to direct the repair process.

Evidence for conservative (two-progeny) DNA double-strand break repair.

TLDR
The results demonstrate the presence of the conservative (two-progeny) double-strand break repair mechanism and set up experimental conditions that should favor detection of conservative ( two-proGeny) recombination.

Repairing a double-strand chromosome break by homologous recombination: revisiting Robin Holliday's model.

TLDR
The establishment of a modified replication fork during DSB repair links gene conversion to another important repair process, break-induced replication, and the essential ideas he proposed of strand invasion and heteroduplex DNA formation, the formation and resolution of HJs, and mismatch repair remain the basis of thinking.

DNA strand-exchange patterns associated with double-strand break-induced and spontaneous mitotic crossovers in Saccharomyces cerevisiae

TLDR
HtDNA patterns in spontaneous COs isolated in either a wild-type background or in a background with elevated levels of reactive oxygen species were similar to those associated with the DSB-induced events, suggesting that DSBs are the major instigator of spontaneous mitotic recombination in yeast.

Gene conversion adjacent to regions of double-strand break repair

TLDR
The use of restriction site mutations in the his3 gene is described to detect conversion events flanking but outside of a region of a double-strand break repair, consistent with heteroduplex DNA tracts of at least several hundred base pairs adjacent to regions of double-Strand break Repair.

Roles of double-strand breaks in generalized genetic recombination.

  • F. Stahl
  • Biology
    Progress in nucleic acid research and molecular biology
  • 1986
...

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