The double life of a B-1 cell: self-reactivity selects for protective effector functions

@article{Baumgarth2011TheDL,
  title={The double life of a B-1 cell: self-reactivity selects for protective effector functions},
  author={Nicole Baumgarth},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={34-46}
}
During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both… 

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