The double helix: a personal view

  title={The double helix: a personal view},
  author={Francis H. C. Crick},
  • F. Crick
  • Published 26 April 1974
  • Art
  • Nature
Francis Crick reviews the papers published 21 years ago on the structure of DNA and the reaction to them. 
The eternal molecule
A collection of overviews that celebrate the historical, scientific and cultural impacts of a revelatory molecular structure.
"The greatest surprise for everyone"--notes on the 50th anniversary of the double helix.
  • H. Judson
  • Education
    The New England journal of medicine
  • 2003
“It is the molecule which has style, quite as much as the scientists,” Francis Crick wrote in 1974, for the 21st anniversary of the elucidation of the structure of deoxyribonucleic acid, DNA.1
The discovery of the DNA double helix.
  • A. Klug
  • History
    Journal of molecular biology
  • 2004
DNA damage and repair
The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that
The limits of synthetic biology.
Francis Crick in Molecular Biology
This article is a tribute to Francis crick, a biophysicist who passed away on July 28, 2004. Francis crick, James Watson and Maurice Wilkins were jointly awarded the 1962 Nobel Prize for physiology
Applying computational methods in the study of biomolecular systems: The recognition mechanism of DNA repair enzyme Fpg
Stony Brook University Libraries. Department of Chemistry, Lawrence Martin (Dean of Graduate School), Carlos L. Simmerling (Associated Professor, Department of Chemistry), Orlando Scharer (Associated
Local supercoil-stabilized DNA structures.
  • E. Paleček
  • Biology, Chemistry
    Critical reviews in biochemistry and molecular biology
  • 1991
The DNA double helix exhibits local sequence-dependent polymorphism at the level of the single base pair and dinucleotide step, but their occurrence and structural details are dependent on the DNA superhelical density in the cell and can be related to some cellular processes.


Polymorphism of natural DNA.
X-ray fibre diffraction shows that natural very AT-rich DNA exists in at least four novel and distinct conformations depending on the sequence and salt content.
Double Helix at Atomic Resolution
The sodium salt of the dinucleoside phosphate adenosyl-3′,5′-uridine phosphate crystallizes in the form of a right handed antiparallel double helix with Watson-Crick hydrogen bonding between uracil
A crystalline fragment of the double helix: the structure of the dinucleoside phosphate guanylyl-3',5'-cytidine.
The sodium salt of guanylyl-3',5'-cytidine crystallizes in a monoclinic unit cell with one molecule in the asymmetric unit with geometry very similar to those which have been derived from studies of fiber x-ray diffraction patterns of double-stranded RNA, even though the latter do not yield data at atomic resolution.