The double-edged role of 12/15-lipoxygenase during inflammation and immunity.

Abstract

12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators. Although 12/15-LOX has been implicated in the pathogenesis of multiple chronic inflammatory diseases, its physiologic functions seem to include potent immune modulatory properties that… (More)
DOI: 10.1016/j.bbalip.2016.07.014

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