The double cascade of lymphoid proliferation: current challenges and problems areas.

@article{Nossal1984TheDC,
  title={The double cascade of lymphoid proliferation: current challenges and problems areas.},
  author={Gustav J. V. Nossal},
  journal={The American journal of anatomy},
  year={1984},
  volume={170 3},
  pages={253-9}
}
Two largely but not entirely separate cascades of proliferation and differentiation are involved in immunity. First, processes that are mainly independent of the entry of antigen into the body generate the two types of lymphocytes, T cells and B cells. This lymphoneogenesis proceeds in the thymus and the bone marrow, respectively. It creates families and subfamilies of nondividing cells that do nothing but patrol the body until antigen enters. Each lymphocyte set represents a repertoire of… CONTINUE READING