The dose of cyclophosphamide for treating paraquat-induced rat lung injury

Abstract

BACKGROUND/AIMS Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. METHODS Adult male Sprague-Dawley rats were allocated into five groups: control, PQ (35 mg/kg, intraperitoneal injection), and PQ + CP (1.5, 15, or 30 mg/kg). The… (More)
DOI: 10.3904/kjim.2013.28.4.420

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