The dose of cyclophosphamide for treating paraquat-induced rat lung injury

Abstract

BACKGROUND/AIMS Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. METHODS Adult male Sprague-Dawley rats were allocated into five groups: control, PQ (35 mg/kg, intraperitoneal injection), and PQ + CP (1.5, 15, or 30 mg/kg). The dimensions of lung lesions were determined using X-ray microtomography (micro-CT), and histological changes and cytokine levels were recorded. RESULTS The micro-CT results showed that 15 mg/kg CP was more effective than 1.5 mg/kg CP for treating PQ-induced lung injury. At a dose of 1.5 mg/kg, CP alleviated the histological evidence of inflammation and altered superoxide dismutase activity. Using 15 mg/kg CP reduced the elevated catalase activity and serum transforming growth factor (TGF)-β1 level. CONCLUSIONS A CP dose of > 15 mg/kg is effective for reducing the severity of PQ-induced lung injury as determined by histological and micro-CT tissue examination, possibly by modulating antioxidant enzyme and TGF-β1 levels.

DOI: 10.3904/kjim.2013.28.4.420

Extracted Key Phrases

6 Figures and Tables

020040020132014201520162017
Citations per Year

521 Citations

Semantic Scholar estimates that this publication has 521 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{Choi2013TheDO, title={The dose of cyclophosphamide for treating paraquat-induced rat lung injury}, author={Jae-Sung Choi and Sung-Shick Jou and Mee-Hye Oh and Young-Hee Kim and Min-Ju Park and Hyo-wook Gil and Ho-Yeon Song and Sae-Yong Hong}, booktitle={The Korean journal of internal medicine}, year={2013} }