The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells.

@article{Fan2011TheDO,
  title={The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells.},
  author={Jun-jun Fan and Liang-Guo Cao and Tao Wu and De-xin Wang and Dan Jin and Shan Jiang and Zhiyuan Zhang and Long Bi and Guo-xian Pei},
  journal={Molecules},
  year={2011},
  volume={16 12},
  pages={10123-33}
}
Icariin had been reported as a potential agent for osteogenesis, but the dose-effect relationship needed further research to realize the clinical application of icariin. We isolated and purified human bone mesenchymal stem cells (hBMSCs) and stimulated them with different concentrations of icariin. The cytotoxicity of icariin was evaluated by the methylthiazolytetrazolium (MTT) assay method. The proliferation and osteogenic differentiation of such hBMSCs were investigated for different… CONTINUE READING
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