The dosage compensation complex shapes the conformation of the X chromosome in Drosophila.

@article{Grimaud2009TheDC,
  title={The dosage compensation complex shapes the conformation of the X chromosome in Drosophila.},
  author={Charlotte Grimaud and Peter B. Becker},
  journal={Genes & development},
  year={2009},
  volume={23 21},
  pages={
          2490-5
        }
}
The dosage compensation complex (DCC) in Drosophila globally increases transcription from the X chromosome in males to compensate for its monosomy. We discovered a male-specific conformation of the X chromosome that depends on the associations of high-affinity binding sites (HAS) of the DCC. The core DCC subunits MSL1-MSL2 are responsible for this male-specific organization. Contrary to emerging concepts, we found that neither DCC assembly nor the conformation of the male X chromosome are… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

Dosage compensation and nuclear organization: cluster to control chromosome-wide gene expression.

  • Current opinion in genetics & development
  • 2016
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

DNA sequence and the organization of chromosomal domains.

  • Current opinion in genetics & development
  • 2008
VIEW 2 EXCERPTS

Similar Papers

Loading similar papers…