The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression.

@article{Petersen1995TheDI,
  title={The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression.},
  author={Ulla Maja Petersen and Glenn Bj{\"o}rklund and Yicktung Tony Ip and Ylva Engstr{\"o}m},
  journal={The EMBO journal},
  year={1995},
  volume={14 13},
  pages={3146-58}
}
A new member of the Rel family of transcription factors, the dorsal-related immunity factor, Dif, was recently cloned and suggested to be involved in regulating the immune response in Drosophila. Despite its classification as a Rel family member, the Dif cDNA-encoded product has not been proven previously to be a transcription factor. We now present evidence that the Dif gene product trans-activates the Drosophila Cecropin A1 gene in co-transfection assays. The transactivation requires a 40 bp… CONTINUE READING

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