The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease.

@article{Michelsen2008TheDR,
  title={The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease.},
  author={Kimmo A. Michelsen and Jos Prickaerts and Harry W. M. Steinbusch},
  journal={Progress in brain research},
  year={2008},
  volume={172},
  pages={233-64}
}
The dorsal raphe nucleus (DRN) is a heterogeneous brainstem nucleus located in the midbrain and pons. Via widespread projections, which target a multitude of brain areas, its neurons utilize many transmitters to control various physiological functions, including learning, memory and affect. Accordingly, the DRN has been strongly associated with brain dysfunction, especially mood disorders such as depression, but also Alzheimer's disease. The DRN's most abundant transmitter, serotonin, has… CONTINUE READING
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