The dorsal raphe nucleus--from silver stainings to a role in depression.

@article{Michelsen2007TheDR,
  title={The dorsal raphe nucleus--from silver stainings to a role in depression.},
  author={Kimmo A. Michelsen and Christoph Schmitz and Harry W. M. Steinbusch},
  journal={Brain research reviews},
  year={2007},
  volume={55 2},
  pages={329-42}
}
Over a hundred years ago, Santiago Ramón y Cajal used a new staining method developed by Camillo Golgi to visualize, among many other structures, what we today call the dorsal raphe nucleus (DRN) of the midbrain. Over the years, the DRN has emerged as a multifunctional and multitransmitter nucleus, which modulates or influences many CNS processes. It is a phylogenetically old brain area, whose projections reach out to a large number of regions and nuclei of the CNS, particularly in the… CONTINUE READING