The dopaminergic hyper‐responsiveness of the shell of the nucleus accumbens is hormone‐dependent

  title={The dopaminergic hyper‐responsiveness of the shell of the nucleus accumbens is hormone‐dependent},
  author={Michel Barrot and Michela Micky Marinelli and Djoher Nora Abrous and Françoise Rougé-Pont and Michel Le Moal and Pier Vincenzo Piazza},
  journal={European Journal of Neuroscience},
The dopaminergic projection to the shell of the nucleus accumbens is the most reactive to stress, reward and drugs of abuse and this subregion of the nucleus accumbens is also considered a target of therapeutic effects of atypical antipsychotic drugs (APD). In this report we show, by means of in vivo microdialysis and Fos immunohistochemistry, that the hyper‐responsiveness which characterizes the dopaminergic transmission to the shell is dependent on glucocorticoid hormones. In Sprague‐Dawley… 

Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum

It is shown that, in the dorsolateral striatum, glucocorticoids modify postsynaptic dopaminergic transmission, highlighting the profound heterogeneous influence of glucocORTicoids within dopamine projections.

Catecholamine mapping within nucleus accumbens: differences in basal and amphetamine‐stimulated efflux of norepinephrine and dopamine in shell and core

The norepinephrine response was greater and long‐lasting in shell compared with core, but the duration of the effect was comparable in both regions, and the distinct neurochemical characteristics of shell and core are likely to contribute to the functional heterogeneity of the two subregions.

Chronic Hypercortisolemia Inhibits Dopamine Synthesis and Turnover in the Nucleus accumbens: An in vivo Microdialysis Study

Results indicate that CORT inhibits DA synthesis and turnover in the NAc but not in the PFC, and region-specific CORT-induced inhibition of DAergic activity may help to explain depressive symptoms in patients with chronichypercortisolemia and normalization after medical or surgical correction of hypercortisolism.

Corticosterone regulates both naturally occurring and cocaine‐induced dopamine signaling by selectively decreasing dopamine uptake

The results suggest that corticosterone interferes with naturally occurring dopamine uptake locally, and this effect is a critical determinant of dopamine concentration specifically in situations in which the dopamine transporter is pharmacologically blocked by cocaine.

Stress-induced changes in nucleus accumbens glutamate synaptic plasticity.

It is hypothesized that altered information processing via plasticity of excitatory inputs might contribute to reward-related behaviors such as stress-induced reinstatement of drug seeking in animals and relapse in humans.

Dopamine efflux in nucleus accumbens shell and core in response to appetitive classical conditioning

Unlike previous conditioning paradigms involving either a more salient US or a more complex CS, the present paradigm, using normal reward pellets as US and a discrete auditory stimulus as CS, did not lead to differential responses in dopamine efflux in shell and core subregions of the nucleus accumbens.



Functional heterogeneity in dopamine release and in the expression of Fos‐like proteins within the rat striatal complex

The nucleus accumbens shell seems to be the area of the striatal complex most functionally reactive to stress and drugs of abuse, but the dorsolateral striatum and the core appear functionally distinct, as for most of the parameters studied these two regions differed.

A dopamine‐μ1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non‐psychostimulant drugs of abuse

The results indicate that μ1 opioid receptors in the ventral tegmentum play a major role in the stimulant effects of food and drugs of abuse on mesolimbic dopamine transmission.

Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone‐replacement

Chronic stress increases the vulnerability to develop psychostimulant selfadministration in a glucocorticoid-responsive manner, and rats have been shown to intravenously self-administer CORT, which suggests an important role of CORT in reward related brain processes.

Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.

In vivo neurochemical evidence is provided for a functional compartmentation within the nucleus accumbens and for a preferential effect of psychostimulants and morphine in the shell of the nucleus Accumbens at doses known to sustain intravenous drug self-administration.

Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex

Rats learned to lever-press when such behavior was reinforced by microinjections of phencyclidine (PCP) directly into the ventromedial (shell) region of nucleus accumbens, indicating that the drug

Suppression of glucocorticoid secretion and antipsychotic drugs have similar effects on the mesolimbic dopaminergic transmission.

  • P. PiazzaM. Barrot M. Le Moal
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
Findings suggest that blockade of central effects of glucocorticoids might open new therapeutic strategies of behavioral disturbances.

Corticosterone circadian secretion differentially facilitates dopamine- mediated psychomotor effect of cocaine and morphine

The results show that suppression of corticosterone by adrenalectomy reduced the locomotor response to cocaine and morphine, injected both systemically and centrally.

Dopamine-dependent responses to morphine depend on glucocorticoid receptors.

Glucocorticoid hormones, via GRs, facilitate the dopamine-dependent behavioral effects of morphine, probably by facilitating dopamine release, which may open new therapeutic strategies for treatment of drug addiction.