The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks.

@article{Bertorello2005TheDP,
  title={The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks.},
  author={Alejandro Mario Bertorello and Jacob I Sznajder},
  journal={American journal of respiratory cell and molecular biology},
  year={2005},
  volume={33 5},
  pages={
          432-7
        }
}
Stimulation of dopamine receptors in the lung or kidney epithelia has distinct and opposite effects on the function of Na,K-ATPase, which results in increased Na(+) absorption across the alveolar epithelium and increased sodium excretion via the kidney epithelium. In the lung, dopamine increases Na,K-ATPase by increasing cell basolateral surface expression of Na(+),K(+)-ATPase molecules, whereas in the kidney epithelia it decreases Na(+),K(+)-ATPase activity by removing active units from the… CONTINUE READING
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