The dopamine hypothesis of drug addiction: hypodopaminergic state.

@article{Melis2005TheDH,
  title={The dopamine hypothesis of drug addiction: hypodopaminergic state.},
  author={Miriam Melis and Saturnino Spiga and Marco Diana},
  journal={International review of neurobiology},
  year={2005},
  volume={63},
  pages={
          101-54
        }
}
Publisher Summary This chapter presents the dopamine (DA) hypothesis of drug addiction. Drug addiction is a brain disorder caused by the repetitive use of various chemicals that alter the normal functioning of the central nervous system with consequent behavioral abnormalities. A neurotransmitter system (the mesolimbic DA system) appears to be modified in its functioning more than others, and appears to fluctuate differently and predictably depending on acute drug challenge, chronic drug… CONTINUE READING

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