The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals

@article{Yoshioka2002TheDA,
  title={The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals},
  author={Michiyo Yoshioka and Ken-ichi Tanaka and Ikuko Miyazaki and Naoko Fujita and Norio Ogawa},
  journal={Neuroscience Research},
  year={2002},
  volume={43},
  pages={259-267}
}
Free radicals are involved in the pathogenesis and/or progression of Parkinson's disease (PD). Several ergot derivative dopamine (DA) agonists have been reported to scavenge free radicals in vitro and to show a neuroprotective effect in vivo. We investigated the in vitro free radical scavenging and antioxidant activities of cabergoline, a long-acting ergot DA agonist, as well as its ability to activate glutathione (GSH), catalase (Cat) and superoxide dismutase (SOD) activating effects and its… CONTINUE READING

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