The dopamine D3-receptor: A postsynaptic receptor inhibitory on rat locomotor activity

@article{Waters2005TheDD,
  title={The dopamine D3-receptor: A postsynaptic receptor inhibitory on rat locomotor activity},
  author={Nicholas Waters and Kjell A. Svensson and Susanne R. Haadsma-Svensson and M. W. Smith and Arvid Carlsson},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={94},
  pages={11-19}
}
We report on the pharmacological effects of the 20 fold D 3 vs. D 2 dopamine receptor preferring compound U 99194 A. It is shown that U 99194 A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the striatum or the nucleus accumbens significantly. The data do not support any direct agonist action of U 99194 A at dopamine receptors. It is suggested that U 99194 A can antagonise a population of postsynaptic dopamine receptors involved in the… 
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115 Citations

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Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release
TLDR
The hypothesis that the dopamine D3 receptor is a postsynaptic receptor with an inhibitory influence on rat locomotor activity is supported.
The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion
Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour
TLDR
Support is given for the hypothesis that the dopamine D3 receptor is functionally relevant at the postsynaptic level and proposed to exert an inhibitory influence on psychomotor functions.
Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011
TLDR
Comparing the effects of dopamine D3 antagonists with different levels of selectivity over D2 receptors on motor activity as well as on agonist-induced hypoactivity, in mice and rats found significant species differences and movement-type differences were observed.
Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain
TLDR
The hypothesis that dopamine D3 receptors (in contrast to the D2 receptors) are mainly postsynaptically located where they display an inhibitory action on locomotor activity is supported.
Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
TLDR
It is reported that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve.
Selective Antagonism at Dopamine D3 Receptors Prevents Nicotine-Triggered Relapse to Nicotine-Seeking Behavior
TLDR
The results suggest that DA D3 receptors are involved in the reinstatement of nicotine-seeking behavior independently of any interaction with the primary reinforcing effects of nicotine itself, and point toward the potential use of selective D3 receptor antagonists for the pharmacotherapeutic management of relapse to drug-seeking behaviors.
Molecular Evidence for the Functional Role of Dopamine D3 Receptor in the Morphine-Induced Rewarding Effect and Hyperlocomotion
TLDR
Findings provide further evidence that dopamine D3 receptor contributes to the postsynaptically negative modulation of the mesolimbic dopaminergic pathway that is associated with the rewarding effect and hyperlocomotion through the stimulation of μ-opioid receptors induced by morphine in the mouse.
Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat
TLDR
The present results suggest that the dopamine D3 receptor, in contrast to the D2 receptor, has an inhibitory influence on reward mechanisms.
The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
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