The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders.

@article{Comings1991TheDD,
  title={The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders.},
  author={David E. Comings and B G Comings and Donn Muhleman and Gerhard Dietz and B Shahbahrami and D E Tast and Ellen Knell and P{\'a}l Kocsis and R. Baumgarten and Bruce W. Kovacs},
  journal={JAMA},
  year={1991},
  volume={266 13},
  pages={1793-800}
}
OBJECTIVE --The A1 allele of the Taq I polymorphism of the dopamine D2 receptor (DRD2) gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of controls. Other research has reported no significant difference in the prevalence of the A1 allele in alcoholics vs controls and no evidence that the DRD2 gene was linked to alcoholism. We hypothesized that these seemingly conflicting results might be because increases in the prevalence of the A1 allele may not be specific to… CONTINUE READING
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