The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice.

@article{Ralph1999TheDD,
  title={The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice.},
  author={Rebecca J. Ralph and Geoffrey B. Varty and Michele A. Kelly and Ying Wang and Marc G. Caron and Marcelo Gonçalves Rubinstein and David Kilgore Grandy and Malcolm J Low and Mark A. Geyer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 11},
  pages={
          4627-33
        }
}
Brain dopamine (DA) systems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibition (PPI). The class of D2-like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the control of PPI via studies of DA agonists and antagonists in rats. Nevertheless, the functional relevance of each receptor subtype remains unclear because these ligands are not specific. To determine the relevance of each receptor subtype, we used… CONTINUE READING

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