The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis.

@article{Chott1996TheDT,
  title={The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis.},
  author={Andreas Chott and Eric C. Vonderheid and Sigrid Olbricht and Nae-Fang Miao and Steven P. Balk and Marshall Edward Kadin},
  journal={The Journal of investigative dermatology},
  year={1996},
  volume={106 4},
  pages={696-700}
}
This study was undertaken to determine the clonality of lymphomatoid papulosis (LyP), its clonal relationship to lymphomas, which occur at high frequency in LyP patients, and to define the cell lineage of Reed-Sternberg-like cells in type A lesions of LyP. Punch biopsies of skin of 11 adult patients with LyP were analyzed for morphologic subtype of LyP, surface antigens, and clonal T-cell receptor (TCR) gene rearrangements. Clonal rearrangements were identified by semiquantitative polymerase… CONTINUE READING