The domain of platelet glycoprotein I as recognized by various antibodies, both monoclonal and polyspecific.

Abstract

Platelet membrane glycoprotein Ib plays a major role in the binding of factor VIII/von Willebrand factor to allow platelet adhesion to subendothelium. We have used polyspecific and monoclonal antibodies to glycoprotein Ib and have demonstrated that both antibodies were directed to glycoprotein Is, a soluble fragment of glycoprotein Ib. By showing an inhibition of the binding of factor VIII/von Willebrand factor to control platelets in presence of the antibodies, it can be concluded that glycoprotein Is is involved in these binding sites.

Cite this paper

@article{Bryckaert1983TheDO, title={The domain of platelet glycoprotein I as recognized by various antibodies, both monoclonal and polyspecific.}, author={Marijke Bryckaert and Chang Ruan and G M Tobelem}, journal={Blood cells}, year={1983}, volume={9 2}, pages={383-7} }