The dolabellane diterpene Dolabelladienetriol is a typical noncompetitive inhibitor of HIV-1 reverse transcriptase enzyme.

@article{CirneSantos2008TheDD,
  title={The dolabellane diterpene Dolabelladienetriol is a typical noncompetitive inhibitor of HIV-1 reverse transcriptase enzyme.},
  author={Cl{\'a}udio C{\'e}sar Cirne-Santos and Thiago Moreno Lopes e Souza and Val{\'e}ria Laneuville Teixeira and Carlos Frederico Leite Fontes and Moacyr Alcoforado Rebello and Lu{\'i}z Roberto Ribeiro Castello-Branco and Celina Monteiro Abreu and Amilcar Tanuri and Izabel Chistina de Palmer Paix{\~a}o Frugulhetti and Dumith Chequer Bou-Habib},
  journal={Antiviral research},
  year={2008},
  volume={77 1},
  pages={64-71}
}
We recently described that a dollabelane diterpene isolated from the marine algae Dictyota pfaffii (Dolabelladienetriol) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and HIV-1 replication in primary cells. Based on these findings, we investigated additional antiretroviral properties of Dolabelladienetriol. Here, we describe that Dolabelladienetriol blocked the synthesis and integration of HIV-1 provirus and completely abrogated viral replication in… CONTINUE READING
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