The diversity of histone versus nonhistone sirtuin substrates.

  title={The diversity of histone versus nonhistone sirtuin substrates.},
  author={Paloma Mart{\'i}nez-Redondo and Alejandro Vaquero},
  journal={Genes & cancer},
  volume={4 3-4},
The members of the Sir2 family, or sirtuins, are major regulators of the response to different types of stress. The members of the family have adapted to increasing complexities throughout evolution and have become diversified by increasing their number, specificity, and localization and acquiring novel functions. Sirtuins have been consistently implicated in the cross-talk between the genomic information and environment from the prokaryotes onward. Evidence suggests that in the transition to… CONTINUE READING
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