The diversity of bioactive proteins in Australian snake venoms.

  title={The diversity of bioactive proteins in Australian snake venoms.},
  author={Geoff W. Birrell and Stephen T H Earl and Tristan P Wallis and Paul P. Masci and John de Jersey and Jeffrey John Gorman and Martin Francis Lavin},
  journal={Molecular & cellular proteomics : MCP},
  volume={6 6},
Australian elapid snakes are among the most venomous in the world. Their venoms contain multiple components that target blood hemostasis, neuromuscular signaling, and the cardiovascular system. We describe here a comprehensive approach to separation and identification of the venom proteins from 18 of these snake species, representing nine genera. The venom protein components were separated by two-dimensional PAGE and identified using mass spectrometry and de novo peptide sequencing. The venoms… CONTINUE READING