The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype.

@article{Melo1996TheDO,
  title={The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype.},
  author={Junia V. Melo},
  journal={Blood},
  year={1996},
  volume={88 7},
  pages={2375-84}
}
HE PHILADELPHIA (Ph) chromosome was the first T chromosomal abnormality associated with a specific malignant disease in humans, namely chronic myeloid leukemia (CML).’ Later it was identified as one partner in a reciprocal translocation between chromosomes 9 and 22, referred to as t(9;22)(q34;q11).2 We know now that this translocation results in the formation of two hybrid genes, BCR-ABL on the Ph chromosome and ABL-BCR on 9q+. The BCR-ABL gene encodes a fusion protein with elevated tyrosine… CONTINUE READING
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