The divergent eukaryote Trichomonas vaginalis has an m7G cap methyltransferase capable of a single N2 methylation

  title={The divergent eukaryote Trichomonas vaginalis has an m7G cap methyltransferase capable of a single N2 methylation},
  author={A. Simoes-Barbosa and Camila Louly and O. L. Franco and M. A. Rubio and J. Alfonzo and P. Johnson},
  journal={Nucleic Acids Research},
  pages={6848 - 6858}
Eukaryotic RNAs typically contain 5′ cap structures that have been primarily studied in yeast and metazoa. The only known RNA cap structure in unicellular protists is the unusual Cap4 on Trypanosoma brucei mRNAs. We have found that T. vaginalis mRNAs are protected by a 5′ cap structure, however, contrary to that typical for eukaryotes, T. vaginalis spliceosomal snRNAs lack a cap and may contain 5′ monophophates. The distinctive 2,2,7-trimethylguanosine (TMG) cap structure usually found on… Expand
Characterization of a mimivirus RNA cap guanine-N2 methyltransferase.
A Metazoan/Plant-like Capping Enzyme and Cap Modified Nucleotides in the Unicellular Eukaryote Trichomonas vaginalis
Multiplicity of 5′ Cap Structures Present on Short RNAs
Responsiveness of Trichomonas vaginalis to iron concentrations: evidence for a post-transcriptional iron regulation by an IRE/IRP-like system.
  • J. Torres-Romero, R. Arroyo
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2009
Interactions between Giardia duodenalis Sm proteins and their association with spliceosomal snRNAs
3′ processing in protists


Characterization of the Trypanosoma brucei cap hypermethylase Tgs1.
The TbMTr1 Spliced Leader RNA Cap 1 2 ′-O-Ribose Methyltransferase from Trypanosoma brucei Acts with Substrate Specificity*
Specificity and Mechanism of RNA Cap Guanine-N2 Methyltransferase (Tgs1)*
Giardia lamblia RNA Cap Guanine-N2 Methyltransferase (Tgs2)*
Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides.
Yeast-like mRNA Capping Apparatus in Giardia lamblia*
Initiator Recognition in a Primitive Eukaryote: IBP39, an Initiator-Binding Protein from Trichomonas vaginalis