The divergent domains of the NEFA and nucleobindin proteins are derived from an EF-hand ancestor.

@article{Karabinos1996TheDD,
  title={The divergent domains of the NEFA and nucleobindin proteins are derived from an EF-hand ancestor.},
  author={Anton Karabinos and Debashish Bhattacharya and Corinna Morys-Wortmann and Karsten Kroll and Gerrit Hirschfeld and Hartmut D. Kratzin and Shitsu Barnikol-Watanabe and Norbert Hilschmann},
  journal={Molecular biology and evolution},
  year={1996},
  volume={13 7},
  pages={990-8}
}
The human protein NEFA (DNA binding, EF-hand, Acidic region) has previously been isolated from a KM3 cell line and immunolocalized on the plasma membrane, in the cytoplasma, and in the culture medium. Sequence analysis of a cDNA clone encoding NEFA identified a hydrophilic domain, two EF-hands, and a leucine zipper at the C-terminus. These characters are shared with nucleobindin (Nuc). In this paper we have further characterized NEFA and probed its evolutionary origins. Circular dichroism (CD… CONTINUE READING

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