The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype.

@article{Biesinger1990TheDB,
  title={The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype.},
  author={Brigitte Biesinger and John J. Trimble and Ronald C Desrosiers and Burkhard Fleckenstein},
  journal={Virology},
  year={1990},
  volume={176 2},
  pages={505-14}
}
Herpesvirus saimiri strains can be divided into at least three subgroups (A, B, C) based on sequence divergence at the left end of viral unique sequence DNA. Strains of subgroups A and C are highly oncogenic and readily transform simian T-lymphocytes in vitro to interleukin-2 independent growth, while subgroup B strains do not. A left terminal reading frame of a H. saimiri subgroup A strain was shown previously to correlate with the oncogenic phenotype and in vitro transforming potential; the… CONTINUE READING

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