The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.

@article{Parker2013TheDA,
  title={The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.},
  author={Mark D. Parker and Walter F. Boron},
  journal={Physiological reviews},
  year={2013},
  volume={93 2},
  pages={803-959}
}
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2. Each plays a specialized role in maintaining intracellular pH and, by contributing to the movement of HCO3(-) across epithelia… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS