The diurnal rhythm of bone resorption in the rat. Effect of feeding habits and pharmacological inhibitors.

@article{Mhlbauer1995TheDR,
  title={The diurnal rhythm of bone resorption in the rat. Effect of feeding habits and pharmacological inhibitors.},
  author={Roman C. M{\"u}hlbauer and Herbert Andre Fleisch},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 4},
  pages={1933-40}
}
Prevention of low bone mass is important to reducing the incidence of osteoporotic fractures. This paper shows that, in rats, bone mass can be increased by feeding habits per se. Using six-hourly urinary excretion of [3H]tetracycline from prelabeled rats to monitor bone resorption, we previously found a peak of bone resorption following food administration. We now demonstrate that dividing the solid and liquid intake into portions blunts this peak and leads to a decrease in 24-h bone resorption… CONTINUE READING
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