The disulfide relay of the intermembrane space of mitochondria: an oxygen-sensing system?


The intermembrane space of mitochondria contains many proteins that lack classical mitochondrial targeting sequences. Instead, these proteins often show characteristic patterns of cysteine residues that are critical for their accumulation in the organelle. Import of these proteins is catalyzed by two essential components, Mia40 and Erv1. Mia40 is a protein… (More)
DOI: 10.1196/annals.1427.005


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