The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria.

@article{Drsam2016TheDC,
  title={The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria.},
  author={Bastian D{\"o}rsam and J{\"o}rg Fahrer},
  journal={Cancer letters},
  year={2016},
  volume={371 1},
  pages={
          12-9
        }
}
The endogenous disulfide α-lipoic acid (LA) is an essential mitochondrial co-factor. In addition, LA and its reduced counterpart dihydro lipoic acid form a potent redox couple with antioxidative functions, for which it is used as dietary supplement and therapeutic. Recently, it has gained attention due to its cytotoxic effects in cancer cells, which is the key aspect of this review. We initially recapitulate the dietary occurrence, gastrointestinal absorption and pharmacokinetics of LA… CONTINUE READING
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