The disulfide bond structure of Plasmodium apical membrane antigen-1.

  title={The disulfide bond structure of Plasmodium apical membrane antigen-1.},
  author={Anthony N. Hodder and Pauline E. Crewther and Mary L Matthew and Gavin E. Reid and Robert L. Moritz and Richard J. Simpson and Robin F. Anders},
  journal={The Journal of biological chemistry},
  volume={271 46},
Apical membrane antigen-1 (AMA-1) of Plasmodium falciparum is one of the leading asexual blood stage antigens being considered for inclusion in a malaria vaccine. The ability of this molecule to induce a protective immune response has been shown to be dependent upon a conformation stabilized by disulfide bonds. In this study we have utilized the reversed-phase high performance liquid chromatography of dithiothreitol-reduced and nonreduced tryptic digests of Plasmodium chabaudi AMA-1 secreted… CONTINUE READING
96 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 96 extracted citations

Similar Papers

Loading similar papers…