The distribution of sialic acid receptors of avian influenza virus in the reproductive tract of laying hens.

@article{Wang2015TheDO,
  title={The distribution of sialic acid receptors of avian influenza virus in the reproductive tract of laying hens.},
  author={Jing-yu Wang and Zhan-li Chen and Cheng-shan Li and Xiao-lei Cao and Rui Wang and Chao Guo Tang and Jing-jing Huang and Ching-Dong Chang and Hung-Jen Liu},
  journal={Molecular and cellular probes},
  year={2015},
  volume={29 2},
  pages={
          129-34
        }
}
The susceptibility of the host to influenza virus is determined by the distribution of the sialic acid (SA) receptors on host cell membrane. Avian influenza virus (AIV) preferentially binds to SA α-2,3-galactose (SA α2,3-gal) linked receptors, while human strains bind to sialic acid α2,6-galactose (SA α2,6-gal) linked receptors. Here, we describe the SA patterns and distributions in the reproductive tract of hens by employing two specific lectins, Maackia amurensis agglutinin (MAA) for SA α2,3… CONTINUE READING
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