The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brain.

@article{Fonnum1968TheDO,
  title={The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brain.},
  author={Frode Fonnum},
  journal={The Biochemical journal},
  year={1968},
  volume={106 2},
  pages={
          401-12
        }
}
1. The subcellular distributions of glutamate decarboxylase and aspartate transaminase were studied in rat and guinea-pig brain. 2. Glutamate decarboxylase is localized in the synaptosome fraction. The mean density of the particles containing the enzyme is slightly greater than those derived from cholinergic neurones, though overlap is substantial. 3. The enzyme is readily released from synaptosomes by hypo-osmotic treatment, but in the presence of Ca(2+), Na(+) and K(+) it sediments with… CONTINUE READING

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SHOWING 1-10 OF 10 REFERENCES

J

  • E. Roberts
  • biol. Chem. 236, 503. Stahl, W. L., Smith, J. C…
  • 1961
Highly Influential
5 Excerpts

Biochem

  • V. P. Whittaker
  • J. 106, 412.
  • 1968
Highly Influential
5 Excerpts

In Inhibition in the Nervous System and y-Aminobutyric Acid, p

  • R. W. Albers
  • 196. Ed. by Roberts, E. Oxford: Pergamon Press…
  • 1960
Highly Influential
7 Excerpts

Morphological studies of the fractions have been mainly qualitative

  • Harwood
  • 1966

Biochem

  • R.J.A. Kirkland
  • J. 90, 293.
  • 1964

J

  • R. W. Ryall
  • Neurochem. 11, 131.
  • 1964

J

  • I. A. Sytinski
  • Neurochem. 11, 701. Sisken, B., Sano, K. &
  • 1964

Biochem

  • T. Kakefuda
  • Pharmacol. 12, 503. Whittaker, V. P. (). Biochem…
  • 1963

J

  • R. E. Basford
  • Cell Biol. 19, 293. Szerb, J. C. (). J.
  • 1963

J

  • G. R. Webster
  • Neurochem. 5, 164.
  • 1960

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