The distribution of fitness effects of new beneficial mutations in Pseudomonas fluorescens.

@article{McDonald2011TheDO,
  title={The distribution of fitness effects of new beneficial mutations in Pseudomonas fluorescens.},
  author={Michael J. McDonald and Tim F. Cooper and Hubertus J. E. Beaumont and Paul B. Rainey},
  journal={Biology letters},
  year={2011},
  volume={7 1},
  pages={98-100}
}
Theoretical studies of adaptation emphasize the importance of understanding the distribution of fitness effects (DFE) of new mutations. We report the isolation of 100 adaptive mutants-without the biasing influence of natural selection-from an ancestral genotype whose fitness in the niche occupied by the derived type is extremely low. The fitness of each derived genotype was determined relative to a single reference type and the fitness effects found to conform to a normal distribution. When… CONTINUE READING
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The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa

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The distribution of fitness effects among beneficial mutations

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