The distribution of fitness effects of new mutations

  title={The distribution of fitness effects of new mutations},
  author={A. Eyre-Walker and P. Keightley},
  journal={Nature Reviews Genetics},
  • A. Eyre-Walker, P. Keightley
  • Published 2007
  • Medicine, Biology
  • Nature Reviews Genetics
  • The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of the molecular clock. It has been studied by two different approaches: mutation accumulation and mutagenesis experiments, and the analysis of DNA sequence data. The proportion of mutations that are advantageous, effectively neutral and deleterious varies between species, and the DFE differs between coding and… CONTINUE READING

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    The Distribution of Fitness Effects of New Deleterious Amino Acid Mutations in Humans
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