The distribution of cocaine in mice differs by age and strain.

  title={The distribution of cocaine in mice differs by age and strain.},
  author={Lois E McCarthy and Paolo Mannelli and Michelle Niculescu and K Fred Gingrich and Ellen M. Unterwald and Michelle E Ehrlich},
  journal={Neurotoxicology and teratology},
  volume={26 6},
Few studies have examined the influence of the age and the strain of mouse on the pharmacokinetics of psychostimulants, or the role of pharmacokinetics in age-related differences in drug responses. The present study compared concentrations of cocaine, and its metabolite, benzoylecgonine (BZE), in the blood and brain of early (P35) and later (P42) periadolescent and adult (P63) CD-1 and C57BL/6 male mice 15 min after acute intraperitoneal injection of cocaine (20 mg/kg). Brain levels of cocaine… CONTINUE READING

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