The distribution of γ-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen

@article{Nieuwenhuijzen2009TheDO,
  title={The distribution of $\gamma$-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen},
  author={P. V. Nieuwenhuijzen and I. McGregor and G. Hunt},
  journal={Neuroscience},
  year={2009},
  volume={158},
  pages={441-455}
}
gamma-Hydroxybutyrate (GHB) is a euphoric, prosocial and sleep inducing drug that binds with high affinity to its own GHB receptor site and also more weakly to GABA(B) receptors. GHB is efficacious in the treatment of narcolepsy and alcoholism, but heavy use can lead to dependence and withdrawal. Many effects of GHB (sedation, hypothermia, catalepsy) are mimicked by GABA(B) receptor agonists (e.g. baclofen). However other effects (euphoric and prosocial effects and a therapeutic effect in… Expand
A single acute pharmacological dose of γ-hydroxybutyrate modifies multiple gene expression patterns in rat hippocampus and frontal cortex.
TLDR
It is demonstrated that a single acute anesthetic dose of 1 g/kg GHB alters a large number of genes, 121 in hippocampus and 53 in prefrontal cortex; 16 genes were modified simultaneously in both brain regions by using DNA microarray studies. Expand
Regional Fos-expression induced by γ-hydroxybutyrate (GHB): Comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382
TLDR
A surprising lack of reversal of GHB-induced Fos expression is shown by two relevant antagonists, both of which have marked intrinsic actions and may reflect the limited doses tested but also suggest that GHB Fosexpression reflects mechanisms independent ofGHB and GABAB receptors. Expand
Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry.
TLDR
Biotelemetry analysis of the effects of GHB on body temperature and locomotor activity in freely moving rats and interactions between GHB and 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine (METH) and various antagonist drugs confirm a role for GABA(B) receptors in the hypothermic and sedative effects of Ghanaian drug gamma-hydroxybutyrate. Expand
GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy
TLDR
Utility of R-BAC-based therapeutics for narcolepsy suggests the mechanism of action for these therapeutic effects is hypothesized to be GABAB receptor dependent. Expand
γ-Hydroxybutyric acid induces actions via the GABAB receptor in arousal and motor control-related nuclei: Implications for therapeutic actions in behavioral state disorders
TLDR
The data support the conclusion that GHB may be exerting its actions on state and motor control, in part, via an acutely mediated strong inhibition of serotonergic DR neurons and a more modest inhibitory action on a smaller proportion of LDT cholinergic neurons. Expand
Baclofen and gamma-hydroxybutyrate differentially altered behavior, EEG activity and sleep in rats
TLDR
While both Bac and GHB induced a non-physiological resting state, only Bac facilitated and consolidated sleep, and promoted EEG delta oscillations thereafter, and Bac can be considered a sleep-promoting drug and its effects on functional recovery after stroke can be evaluated both in humans and rats. Expand
GABAB receptor activation exacerbates spontaneous spike-and-wave discharges in DBA/2J mice
TLDR
The results indicate that GABA(B) receptor signaling might exert differential effects on SWDs in DBA/2J mice, in comparison with their vehicle-treated controls. Expand
Differential Effects of GABAB Receptor Subtypes, γ-Hydroxybutyric Acid, and Baclofen on EEG Activity and Sleep Regulation
TLDR
Electroencephalogram recordings in mice devoid of functional GABAB receptors or lacking one of the subunit 1 isoforms found that GABAB1a protects against the spontaneous seizure activity observed in 1+/− and 2−/− mice, indicating that all GBL effects are mediated through GABAB receptor effects, although these receptors do not seem to be involved in mediating the BAC-induced hypersomnia. Expand
Differential development of tolerance to the functional and behavioral effects of repeated baclofen treatment in rats
TLDR
These persistent effects on functional activity in the caudate putamen and septum may provide insights into the way in which baclofen alters the reinforcing effects of abused substances such as cocaine, alcohol, and methamphetamine both in humans and animal models. Expand
GHB receptor targets in the CNS: focus on high-affinity binding sites.
TLDR
The main focus will be on the high-affinity binding targets for GHB and their potential functional roles in the mammalian brain. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 113 REFERENCES
Repeated Administration of Gamma‐Hydroxybutyric Acid (GHB) to Mice
TLDR
The development of tolerance to the sedative effects of GHB coupled with the rewarding properties of the drug support the abuse potential ofGHB. Expand
Gamma-hydroxybutyrate increases tryptophan availability and potentiates serotonin turnover in rat brain.
TLDR
The results indicate that the GHB-induced stimulation of tissue serotonin turnover may be due to an increase in tryptophan transport to the brain and in its uptake by serotonergic cells. Expand
Cataleptic effects of γ-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABAB receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists
TLDR
The finding that NMDA receptor antagonists enhance the cataleptic effects of GHB but not those of baclofen is further evidence that the GABAB receptor mechanisms mediating the effects ofGHB and GABAB agonists are not identical. Expand
GABAB receptor-mediated increase of neurosteroids by γ-hydroxybutyric acid
Among the pharmacological actions of gamma-hydroxybutyric acid (GHB), some may involve GABA(A) receptor-mediated mechanisms. GHB, however, fails to directly interact with sites for agonists andExpand
Effects of γ-Hydroxybutyrate (GHB) on Schedule-Controlled Responding in Rats: Role of GHB and GABAB Receptors
TLDR
The ability of CGP 35348 to antagonize the rate-decreasing effects of baclofen may be limited by the involvement of multiple GABAB receptor subtypes and the lack of antagonism of GHB by NCS-382 may be due to its own GHB-like effects. Expand
γ-Hydroxybutyrate is a weak agonist at recombinant GABAB receptors
TLDR
Results indicate that GHB is a weak partial agonist at the GABA binding site of GABA(B)R1/R2, and this hypothesis is consistent with previous reports on GHB and gamma-aminobutyric acid. Expand
Unravelling the brain targets of γ-hydroxybutyric acid
TLDR
There is an urgent need for a well-validated functional assay for GHBRs as it remains to be seen whether the many GABAB receptor-mediated actions of GHB are caused by GHB itself acting directly on GABAB receptors or by a GHB-derived GABA pool (or both). Expand
Role of GABAB receptors in the sedative/hypnotic effect of γ-hydroxybutyric acid
Abstract The present study was aimed at identifying the receptor systems involved in the mediation of the sedative/hypnotic effect of γ-hydroxybutyric acid (GHB) in DBA mice. Administration of theExpand
Discriminative Stimulus Effects of γ-Hydroxybutyrate in Pigeons: Role of Diazepam-Sensitive and -Insensitive GABAA and GABAB Receptors
γ-Hydroxybutyrate (GHB) is an emerging drug of abuse with multiple mechanisms of action. This study is part of an effort to examine the role of GHB, GABAA, and GABAB receptors in the discriminativeExpand
Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol
TLDR
The data suggest that the effects of low doses of alcohol may be due to selective GABA-like effects of ethanol, whereas higher doses of ethanol involve effects on multiple neurotransmitter systems. Expand
...
1
2
3
4
5
...