The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.

@article{Yip2007TheDR,
  title={The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.},
  author={S. Yip and Mirvat El-Sibai and Salvatore J. Coniglio and Ghassan Mouneimne and Robert J. Eddy and Beth E. Drees and Paul O. Neilsen and Sumanta K Goswami and Marc Symons and John S Condeelis and Jonathan M. Backer},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 17},
  pages={3138-46}
}
Cell migration involves the localized extension of actin-rich protrusions, a process that requires Class I phosphoinositide 3-kinases (PI 3-kinases). Both Rac and Ras have been shown to regulate actin polymerization and activate PI 3-kinase. However, the coordination of Rac, Ras and PI 3-kinase activation during epidermal growth factor (EGF)-stimulated protrusion has not been analyzed. We examined PI 3-kinase-dependent protrusion in MTLn3 rat adenocarcinoma cells. EGF-stimulated phosphatidyl… CONTINUE READING

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