The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers

@article{AlHamidi2015TheDE,
  title={The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers},
  author={Hiba Al-Hamidi and Wasfy Obeidat and Ali Nokhodchi},
  journal={Pharmaceutical Development and Technology},
  year={2015},
  volume={20},
  pages={74 - 83}
}
Abstract The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being selected. The work presented explores amino sugars (d-glucosamine HCl and d-gluconolactone) as potential hydrophilic carriers to improve dissolution rate of a poorly water-soluble drug, piroxicam, from physical mixtures and solid dispersion formulations. Solid dispersions of the drug and… 
Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements
Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an additional advantage as it has the ability to overcome
Feasibility of Using Gluconolactone, Trehalose and Hydroxy-Propyl Gamma Cyclodextrin to Enhance Bendroflumethiazide Dissolution Using Lyophilisation and Physical Mixing Techniques
TLDR
The physical mixing and freeze drying processes significantly increased the percentage of drug release with time in bendroflumethiazide and showed a significant enhancement in dissolution rate.
Hydro-alcoholic media effects on theophylline release from sesamum polysaccharide gum matrices
TLDR
The suitability of SG as a matrix former that can resist alcoholic effects therefore makes it suitable as an alternative polymer with wider applications for drug delivery.
Controlling atorvastatin release from liquisolid systems
Abstract Liquisolid technology as a novel technique to control the release rate of drugs has attracted the attention of many researchers. This study aims to investigate parameters controlling the
Piroxicam
TLDR
A comprehensive profile of piroxicam including the nomenclatures, formulae, elemental composition, appearance, uses and applications, and the methods which were utilized for the preparation and analysis are outlined.
Exploring the novel green eutectic solvent for the synthesis of 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2,-benzothiazine-3-carboxamide 1,1-dioxide with benzoic acid cocrystal using a co-grinding technique
In the present study, the suitability of a green eutectic solvent, a mixture of menthol and camphor for cocrystal synthesis has been investigated to improve the biopharmaceutical properties of poorly
Biosurfactant Production Using Mutant Strains of Pseudomonas aeruginosa and Bacillus subtilis from Agro-industrial Wastes
TLDR
The study indicated that the biosurfactant produced by mutant strain of B. subtilis produced more potent activities (surface tension reduction ability, high emulsification) than those of P. aeruginosa.
Comprehensive Rehabilitation Therapy Plus Glucosamine Hydrochloride for Exercise-Induced Knee Injuries and the Effect on Knee Function of Patients
TLDR
Comprehensive rehabilitation therapy plus glucosamine hydrochloride effectively improves the clinical efficacy of exercise-induced knee joint injuries and enhances the knee joint rehabilitation of the patients.
...
...

References

SHOWING 1-10 OF 42 REFERENCES
Formation and characterization of solid dispersions of piroxicam and polyvinylpyrrolidone using spray drying and precipitation with compressed antisolvent.
TLDR
PCA processing could provide an effective pharmaceutical formulation technology to improve the bioavailability of poorly water-soluble drug.
Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers.
  • Naveen AhujaO. KatareBhupinder Singh
  • Chemistry
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2007
The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts.
TLDR
The liquisolid compacts technique can be a promising alternative for the formulation of water insoluble drugs, such as indomethacin into rapid release tablets.
Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.
  • F. DamianN. Blaton G. Van den Mooter
  • Materials Science, Chemistry
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2000
The mechanisms of drug release from solid dispersions in water-soluble polymers.
  • D. Craig
  • Materials Science
    International journal of pharmaceutics
  • 2002
Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs.
  • A. Serajuddin
  • Materials Science
    Journal of pharmaceutical sciences
  • 1999
TLDR
Commercial use of solid dispersion systems during the past four decades has been very limited, primarily because of manufacturing difficulties and stability problems, but this has been changing in recent years because of the availability of surface-active and self-emulsifying carriers and the development of technologies to encapsulate solid dispersions directly into hard gelatin capsules as melts.
...
...