The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl

@article{AlHamidi2015TheDA,
  title={The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl},
  author={Hiba Al-Hamidi and K. Asare-Addo and S. Desai and Mike Kitson and A. Nokhodchi},
  journal={Drug Development and Industrial Pharmacy},
  year={2015},
  volume={41},
  pages={1682 - 1692}
}
Abstract The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any toxic organic solvents. Present work explores the role of d-glucosamine HCl (GL) as a potential excipient to improve dissolution of a low melting point drug, ibuprofen (Ibu), using physical mixtures and coground formulations. The… Expand
The use of various organic solvents to tailor the properties of ibuprofen–glucosamine HCl solid dispersions
Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution ofExpand
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This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic chargesExpand
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Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions
  • K. Asare-Addo, Maen Alshafiee, +9 authors B. Conway
  • Materials Science, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2019
TLDR
All three techniques were successful in improving the dissolution of indomethacin as all three techniques showed that all three methods and the various ratios studied produced amorphous solid dispersions. Expand
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