The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl

  title={The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl},
  author={Hiba Al-Hamidi and Kofi Asare-Addo and Sandip D. Desai and Mike Kitson and Ali Nokhodchi},
  journal={Drug Development and Industrial Pharmacy},
  pages={1682 - 1692}
Abstract The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any toxic organic solvents. Present work explores the role of d-glucosamine HCl (GL) as a potential excipient to improve dissolution of a low melting point drug, ibuprofen (Ibu), using physical mixtures and coground formulations. The… Expand
The use of various organic solvents to tailor the properties of ibuprofen–glucosamine HCl solid dispersions
Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution ofExpand
Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.
This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic chargesExpand
The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets.
Grewia polysaccharide is highlighted as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world. Expand
Freeze-dried crystalline dispersions: Solid-state, triboelectrification and simultaneous dissolution improvements
Abstract The charging propensities of freeze-dried samples produced from combinations of Piroxicam (PXM) - a BCS Class II drug with D-glucosamine HCl (GLU) - a potential hydrophilic carrier wereExpand
Triboelectrification and dissolution property enhancements of solid dispersions.
The results show the selection of solvents can influence powder charge thereby improving powder handling as well as dissolution properties and the method of preparation of the dispersion induced polymorphic forms of the drug. Expand
Direct imaging of the dissolution of salt forms of a carboxylic acid drug
Graphical abstract Figure. No Caption available. HighlightsDecrease in IDR with an increase in chain length of the counterion observed using UV‐imaging.Developed interfacial area ratio (Sdr) showedExpand
Preparation and physicochemical characterization of binary and ternary ground mixtures of carvedilol with PVP and SLS aimed to improve the drug dissolution
According to the results, co-grinding in the presence of PVP and SLS significantly increased CA dissolution rate, and the solubility of this formulation was about 10 times higher compared to that of the intact CA. Expand
Mechanical and release behaviour of theophylline from matrix tablets containing psyllium powder in combination with grewia polysaccharides.
The results showed that grewia polysaccharides may provide an effective reduction and a more sustained drug release from such matrices when overcoming the burst release of drug from matrices such as psyllium. Expand
Towards improved solubility of poorly water-soluble drugs: cryogenic co-grinding of piroxicam with carrier polymers
Cryogenic co-grinding provides a versatile method for preparing amorphous SDs of poorly water-soluble APIs and shows that the carrier polymer influenced both the degree of amorphization of PRX and stabilization against crystallization. Expand
Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions
  • K. Asare-Addo, Maen Alshafiee, +9 authors B. Conway
  • Medicine, Materials Science
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2019
All three techniques were successful in improving the dissolution of indomethacin as all three techniques showed that all three methods and the various ratios studied produced amorphous solid dispersions. Expand


Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.
Results showed that the presence of glucosamine HCl can increase dissolution rate of piroxicam compared to pure piroXicam, and this amino sugar has been shown to decrease pain and improve mobility in osteoarthritis in joints. Expand
Cogrinding as an approach to enhance dissolution rate of a poorly water-soluble drug (gliclazide)
Gliclazide is practically insoluble in water. In order to improve the drug dissolution rate, cogrinding method was used as an approach to prepare gliclazide coground/solid dispersions (SDs) in theExpand
Enhancing Dissolution Rate of Carbamazepine via Cogrinding with Crospovidone and Hydroxypropylmethylcellulose
Reduced crystallinity together with a reduced particle size, enhanced deaggregation and increased wettability of the drug could be accounted for the increased dissolution from the cogrounds. Expand
The Effect of Selected Water-Soluble Excipients on the Dissolution of Paracetamol and Ibuprofen
The purpose of this investigation was to study the dissolution behavior of paracetamol and ibuprofen in the presence of a range of selected potential excipients, and it was established that both drugs dissolved according to the diffusion-layer model. Expand
Improvement of dissolution characteristics and bioavailability of poorly water-soluble drugs by novel cogrinding method using water-soluble polymer
Abstract A novel cogrinding method for improving dissolution characteristics of poorly water-soluble drugs was developed. A coground mixture of nifedipine (NP)-polyethylene glycolExpand
To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.
It has been shown that the use of G-HCl in solid dispersion formulations can significantly enhance the dissolution rate of poorly water-soluble drugs such as carbamazepine. Expand
The use of ordered mixtures for improving the dissolution rate of low solubility compounds& *
It was concluded that the rate limiting step in the dissolution of griseofulvin as the raw material is the penetration of the dissolution medium into the agglomerates. Expand
Effects of grinding on the physicochemical properties of cephalexin powder
The effects of grinding on the physicochemical properties of cephalexin (CEX) were studied by means of water content measurements, differential thermal analysis (DTA), differential scanningExpand
Processing of carbamazepine-PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution.
The dramatic reduction of the dimensions and the better crystal shape, together with the presence of the hydrophilic polymer determined a remarkable enhancement of the in vitro drug dissolution rate. Expand
Physicochemical properties of amorphous clarithromycin obtained by grinding and spray drying.
In order to characterize the amorphous clarithromycin (CAM) obtained by grinding and spray drying, physicochemical properties were evaluated and the increase of the special term, deltas, indicated that the energy change was due to the polarity of the surface energy of the powder particles by grinding. Expand