The disruption of cell cycle checkpoints by papillomavirus oncoproteins contributes to anogenital neoplasia.

@article{Galloway1996TheDO,
  title={The disruption of cell cycle checkpoints by papillomavirus oncoproteins contributes to anogenital neoplasia.},
  author={Denise A. Galloway and James K. McDougall},
  journal={Seminars in cancer biology},
  year={1996},
  volume={7 6},
  pages={309-15}
}
Human cancer are characterized by the failure of cell cycle checkpoints resulting in genetic instability. Human papillomaviruses contribute to the development of anogenital malignancies because the E6 and R7 oncoproteins from high risk HPV types are able to disrupt the integrity of these checkpoints. HPV 16 E7 prevents suprabasal cells from exiting the cell cycle, thus increasing the pool of replicating cells that are available for additional 'hits'. Cells that suffer DNA of chromosome damage… CONTINUE READING

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