The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice.

@article{Kiso2009TheDO,
  title={The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice.},
  author={Makoto Kiso and S. Tanaka and Rie Saba and Satoru Matsuda and Atsushi Shimizu and Manabu Ohyama and Hirotaka James Okano and Toshihiko Shiroishi and Hideyuki Okano and Yumiko Saga},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 23},
  pages={9292-7}
}
Hair is maintained through a cyclic process that includes periodic regeneration of hair follicles in a stem cell-dependent manner. Little is known, however, about the cellular and molecular mechanisms that regulate the layered differentiation of the hair follicle. We have established a mutant mouse with a cyclic alopecia phenotype resulting from the targeted disruption of Sox21, a gene that encodes a HMG-box protein. These mice exhibit progressive hair loss after morphogenesis of the first hair… CONTINUE READING
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